Clinical parameters predicting failure of empirical antibacterial therapy in...
AbstractBackgroundAbout 10-20% of neonates with suspected or proven early onset sepsis (EOS) fail on the empiric antibiotic regimen of ampicillin or penicillin and gentamicin. We aimed to identify...
View ArticleMeropenem vs standard of care for treatment of late onset sepsis in children...
AbstractBackgroundLate onset neonatal sepsis (LOS) with the mortality of 17 to 27% is still a serious disease. Meropenem is an antibiotic with wide antibacterial coverage. The advantage of it over...
View ArticleDrug utilisation pattern and off-label use of medicines in Estonian neonatal...
AbstractObjectivesTo characterise neonatal hospital drug use and to compare the availability of drug information between Estonian Summaries of Product Characteristics (SPCs) and other sources.Study...
View ArticleProlonged outbreak of Serratia marcescens in Tartu University Hospital: a...
AbstractBackgroundThe aim of our study was to investigate and control an outbreak and identify risk factors for colonization and infection with Serratia marcescens in two departments in Tartu...
View ArticleComparison of two alternative study designs in assessment of medicines...
AbstractBackgroundEstimates of prevalence are known to be affected by the design of cross-sectional studies. A pan-European study provided an opportunity to compare the effect of two cross-sectional...
View ArticleCurrent management of late onset neonatal bacterial sepsis in five European...
AbstractLate onset neonatal sepsis (LOS) has a high mortality and the optimal management is poorly defined. We aimed to evaluate new expert panel-derived criteria to define LOS and characterize the...
View ArticleHigh variability in the dosing of commonly used antibiotics revealed by a...
AbstractBackgroundAntibiotic dosing in neonates varies between countries and centres, suggesting suboptimal exposures for some neonates. We aimed to describe variations and factors influencing the...
View ArticleProduct Substitution as a Way Forward in Avoiding Potentially Harmful...
AbstractObjectivesOur objectives were to explore the possibility of avoiding neonatal exposure to potentially harmful excipients of interest (EOI)—parabens, polysorbate 80, propylene glycol, benzoates,...
View ArticleCoagulase negative staphylococcal sepsis in neonates: do we need to adapt...
AbstractBackgroundDespite differences in types of infection and causative organisms, pharmacokinetic-pharmacodynamic (PKPD) targets of vancomycin therapy derived from adult studies are suggested for...
View ArticleEffect of allopurinol in addition to hypothermia treatment in neonates for...
AbstractBackgroundPerinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected...
View ArticleMedicines prescription patterns in European neonatal units
AbstractBackground Hospitalized neonates receive the highest number of drugs compared to all other age groups, but consumption rates vary between studies depending on patient characteristics and local...
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Pharmacokinetics of Gentamicin Components C1, C1a, and C2/C2a/C2b and...
AbstractGentamicin is a commonly used antibiotic in neonates. Its components C1, C1a, C2, C2a, and C2b may have different nephrotoxic potential. We aimed to describe pharmacokinetics and nephrotoxic...
View ArticleThe role of breast milk in the colonization of neonatal gut and skin with...
AbstractBackgroundWe aimed to determine the genetic relatedness between Staphylococcus epidermidis colonizing breast milk (BM) and BM-fed neonates during the first month of life.MethodsS. epidermidis...
View ArticleHigher intake of coagulase-negative staphylococci from maternal milk promotes...
AbstractObjectiveWe aimed to determine factors associated with gut colonization of preterm neonates with coagulase-negative staphylococci (CoNS) from maternal milk (MM).Study DesignCoNS isolated from...
View ArticleGenetic relatedness of Gram-negative bacteria colonizing gut and skin of...
AbstractObjectiveWe described colonization of mother’s own milk with Gram-negative bacteria and its relationship with neonatal colonization.Study DesignGram-negative bacteria isolated from weekly...
View ArticlePharmacokinetics of oral spironolactone in infants up to 2 years of age
AbstractPurposeSpironolactone is a potassium sparing diuretic used for decades. Until now, pharmacokinetic (PK) studies of spironolactone have not been conducted in infants and therefore pediatric...
View ArticleDetailed statistical analysis plan for ALBINO: effect of Allopurinol in...
AbstractBackgroundDespite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe neonatal hypoxic-ischemic encephalopathy (HIE) die or suffer from...
View ArticleSubgroup identification-based model selection to improve the predictive...
AbstractCurrently, model-informed precision dosing uses one population pharmacokinetic model that best fits the target population. We aimed to develop a subgroup identification-based model selection...
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